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Some improvements in insulin sensitivity and inflammatory markers can begin emerging within 4 to 8 weeks of treatment Leptin normalization, however, follows actual fat mass reduction rather than drug exposure directly, meaning those benefits likely take months of sustained treatment

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Semaglutide uses a C18 fatty acid chain with a linker that dramatically increases albumin binding affinity, plus an amino acid substitution at position 8 that prevents DPP-4 degradation