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A 2020 study found that those with vitamin B12 deficiency may present with cognitive disorder, though the deficiency was not shown to be a direct risk factor for cognitive decline ( However, results have been mixed and treatment with vitamin B12 wasnt effective at improving brain function in people with normal brain function ( Depression Its been suggested that there may be a link between low vitamin B12 levels and depression

NAD+ Flux Dynamics: Investigating the interplay between direct coenzyme supplementation and enzymatic inhibition of the salvage pathway