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Inhibition of mitochondrial adaptations and improvements in cardiorespiratory fitness by 50 percent and diminished whole-body insulin sensitivity after aerobic exercise 6 Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults Konopka et al (2018)

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And I wanted to talk to you about this because you're a neuroscientist, that there's something about being in the sauna, I don't know if it has to do with the stress response