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Description

While on GLP-1 RAs, monitoring for vitamin B12 deficiency is recommended

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Sensor dimer disruption as a new mode of action to block the IRE1-mediated unfolded protein response

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It could be speculated that this increased discontinuation rate vs all comparators, including GLP-1 RAs, may be possibly attributed to the severity of gastrointestinal adverse events experienced with tirzepatide 15 mg, considering that the incidence of gastrointestinal adverse events was similar between tirzepatide and GLP-1 RAs

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