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A systematic examination of publications since 2018 informed new recommendations

While many people tolerate GLP-1 medications well, some experience ongoing side effects such as nausea, vomiting, or diarrhoea

However, so far across studies with GLP1R agonists , cardiovascular measurements such as blood pressure have seen improvements in general, with no significant increases in adverse cardiovascular effects seen in patients even after 2 years (In fact, decreases were seen), suggesting that the cardiovascular benefits of decreased body weight may overcome any potential harm that increases in heart rate by GLP1R agonists may cause