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N-terminally truncated GLP-1 and exendin-4 peptides lacking the first 8 amino acids (GLP-1(15-36) and exendin(9-39)), exhibit similar affinities in published studies 31 , to their corresponding full-length peptides in the absence of G protein, providing further support that the influence of G s on peptide affinity is predominantly related to interactions of the N-terminus with the TMD

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These trials were designed to evaluate whether a medication increased cardiovascular risk