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A pilot study of cerebral dialysate from 26 ICU patients with TBI defined two clinically relevant metabolic states based on distinct changes in glucose, lactate and pyruvate as well as metabolites related to ketone metabolism [46]

Clinical research in older humans confirms these mechanisms translate to human aging

A 12-week randomized, placebo-controlled double-blind study found that even a daily dosage of 250 mg of glutathione led to improved skin elasticity and reduced wrinkles compared to a placebo group [9]