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Furthermore, the Hexachlorobenzene pesticide, which was widely used until 1965, through the activation of the integrin-linked kinase (ILK) signaling, modulates the expression of E-cadherin, which plays an important role in BBB dysfunction, facilitating the leukocytes massive influx into the brain parenchyma, which in turn induces irreversible demyelination, tissue damage, and axonal dysfunction (Agency for Toxic Substances and Disease Registry [ATSDR], 2022)

Acyl-CoA synthetase long-chain family member 4 (ACSL4

model 4 had rhythmic genes in both groups with identical acrophase and amplitude (unaltered rhythm)

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