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However, the field is not staying still, and recently published data from the high-dose semaglutide STEP Phase 3 trials (44) and the SURPASS Phase 3 trials of the GLP-1/glucose-dependent insulinotropic peptide (GIP) co-agonist tirzepatide (90) have set the efficacy bar high in terms of weight loss and glycaemic improvement

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The next frontier in medicine may already be hereGLP-1 medications are transforming healthcare in ways no one expected

302 Elevated hepatic iron levels may lead to MAFLD and promote the progression of the disease, with excessive iron content may increase hepatocyte swelling, inflammation, and fibrosis, potentially converting isolated steatosis to MASH