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FDA consumer context worth knowing: The FDA has published consumer guidance expressing concerns about unapproved GLP-1 products marketed for weight loss, including quality and dosing concerns and, in some cases, products that may use semaglutide salt forms that are not the same active ingredient as the FDA-approved reference drug

Regulators may consider the complete claims, presentation, intended purpose and pharmacological context

Contrary to this, intraperitoneal administration of GLP-1 agonists does not stimulate vagal afferents 33 , only a small subset of GLP-1R-expressing vagal afferents innervate the intestinal mucosa where GLP-1 cells reside 33,34 , and ablation of vagal GLP-1R neurons doesnt prevent GLP-1Rs satiating effects 35

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