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Although the precise mechanisms linking this to lung inflammation have not been fully elucidated, the likelihood that this may be involved in lung diseases is suggested by the vast and growing evidence for the role of mtDNA in sterile inflammatory conditions ( Apoptosis has been shown to be an important mode of cell death in several lung diseases and more recently it is appreciated that some cell types can undergo caspase-independent apoptosis ( 4.2 mtDNA-induced inflammatory responses Akin to bacteria, mtDNA contains hypomethylated CpG motifs that are potent inducers of inflammation (Figure 2)

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