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The trend predictions by sex, along with their joinpoint analysis, indicate that the malefemale gap in smoking prevalence has declined in more recent times, particularly among the younger age groups, due to a higher percentage change among male adults

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These changes are believed to play a role in the modulation of the inflammatory response in UC, with some studies indicating that smoking can promote the expression of genes that protect against inflammation in the short term, while also inducing detrimental long-term effects 41

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