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However, in dusty environments or homes with pets, the filters may need to be replaced sooner, and the impactors may need to be cleaned more often

Recessive mutations in genes coding for enzymes of the kynurenine pathway namely kynureninase and 3-hydroxyanthranilic-acid 3,4-dioxygenase lead to combined vertebral, anal, cardiac, tracheo-esophageal, renal, and limb (VACTERL) congenital malformations (76)

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