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AGEs/RAGE stimulation activates immune cells, resulting in NADPH oxidase (NOX) overexpression, which is a primary cytoplasmic source of free radicals and pro-inflammatory factors such as tumor necrosis factor- (TNF-), interleukin 1 (IL-1) and interleukin 6 (IL-6) 5,6,7,8

And they can be incredibly effective, especially when used over a long stretch of time

Acute kidney injury is a frequent complication in critically ill neonates receiving extracorporeal membrane oxygenation: a 14-year cohort study

Regarding the mechanism of action of the dual agonist, it is well-appreciated that GLP-1 acts centrally and in peripheral tissues to regulate energy and glucose homeostasis [74]