S4), suggesting that pro-inflammatory factors may participate in hyperglycemia of Insr P1195L/ +/HFD mice in addition to the unsuppressed glycerol release
Mechanism of Action AOD9604 exerts its metabolic effects through mechanisms that remain incompletely characterized but appear to involve direct stimulation of lipolysis and inhibition of lipogenesis in adipose tissue through pathways independent of the classical growth hormone receptor
The 0.01 mg/kg dose that showed consistent effects in rats translates to approximately 0.0016 to 0.004 mg/kg in humans, which works out to roughly 0.112 to 0.28 mg for a 154-pound person
[DOI] [PubMed] [Google Scholar] 97.Petrovic I., Dobric I., Drmic D., Sever M., Klicek R., Radic B., Brcic L., Kolenc D., Zlatar M., Kunjko K., et al