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Interestingly, semaglutide reduced plasma levels of KC/GRO (also known as CXCL1) and TNF- in Glp1r Tie2+/+ mice but not in Glp1r Tie2/ mice, whereas no treatment or genotype effects were evident in analysis of circulating IL-10 (Figure 3D)

(105) employed untargeted metabolomics and 16S rRNA gene sequencing to reveal significant alterations in serum metabolites and gut microbiota composition in DKD rats, primarily involving carbohydrate, lipid, and amino acid metabolism, with phenylalanine, tyrosine, and tryptophan metabolic pathways being significantly enriched

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