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doi: 10.1074/jbc.R117.779678

Serial studies from the US and Europe suggest that energy expenditure from physical activity increased between 1981 and 2017, during the onset of the obesity epidemic, while basal metabolic expenditure declined, implicating other factors such as dietary composition that impact metabolic rate [86]

(6) Sustained-release formulations

Several case studies have reported the onset of mania and rapid-cycling bipolar disorder following cerebellar lesions caused by either surgery or trauma, which indicates a potential role for the cerebellum in the pathophysiology of bipolar disorder [110,111,112]