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Subsequent reviews have reinforced this finding, suggesting GLP-1s may dampen reward signaling in the brains dopamine pathways, which are involved in addiction and compulsive behaviors (Kalra et al., 2024

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Tirzepatide tends to be the stronger option when maximum weight loss is the priority, when you have significant insulin resistance, or when you have plateaued on semaglutide and need a different approach

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