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To account for variations in region lengths between main and pseudogene RNUs, the mode distance was used to scale the signal for each RNU class as follows: RNU1 (116 genes, 163 nt), RNU2 (39 genes, 190 nt) and RNU6 (505 genes, 106 nt)

The formation of HSPs in ME/CFS individuals is reduced (302), and the responses of plasma HSP27 and HSP70 are delayed or lowered, while resting levels of plasma HSP70 are also decreased (303)

The consequent impairment in oxalate homeostasis can trigger localized and systemic inflammation, progressive kidney disease and cardiovascular complications, including sudden cardiac death