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In most Gram-negative bacteria, the TS is backed up by a glutathione-glutaredoxin (GSH) system that is also able to scavenge reactive oxygen and nitrogen species in order to maintain redox homeostasis ( Helicobacter pylori proves to be an exception to the classification rule as a GSH-independent bacterium ( Mycobacterium tuberculosis , which does not fit within the Gram classification, is TrxR-dependent and GSH-independent ( Staphylococcus spp., Streptococcus spp., Enterococcus spp., or the exceptional GSH independent bacteria H
Overexpression of CXCR4 is significantly associated with cisplatin-based chemotherapy resistance and can be a prognostic factor in epithelial ovarian cancer
the antioxidant enzymes and the non-antioxidant metabolites, work in conjunction to alleviate the damaging effects of ROS and develop tolerance against various environmental stress conditions
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