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As the ghrelin receptor also regulates growth hormone release, it can boost muscle growth (8, 9)

Drugs that extend the life of GLP-1 have been around for over 20 years, Jastreboff noted

Pulse-dependent transcriptional control The liver and other peripheral tissues interpret pulse frequency as a distinct regulatory code

She said several factors explain their rapid adoption: They significantly reduce appetite and help people eat less without constant hunger Some are FDA-approved for chronic weight management in people who meet eligibility criteria There is growing recognition in healthcare that obesity is a chronic disease, not simply a willpower issue, and may require long-term medical treatment Their popularity also reflects strong public awareness and patient demand, though cost, access, and insurance coverage remain major barriers for many people, Araghi said