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second, it binds to cellular GST/GSH, depleting its intracellular content to weaken the efflux of chemotherapy drugs in tumor cells

Other relevant interactions: Colchicine (used for gout) may affect B12 absorption with long-term use Chloramphenicol (rarely used antibiotic) may blunt the haematological response to B12 treatment Monitoring considerations: Patients taking loop or thiazide diuretics require careful monitoring when initiating B12 therapy in severe deficiency, due to the risk of hypokalaemia during rapid cell production

2 Metabolic features of preeclampsia The nutrients that can regulate the development of preeclampsia include carbohydrates, lipids, amino acids and glycans, which can have a principal effect on placental energy supply, inflammatory response, vasoconstriction, oxidative stress, trophoblast autophagy and vascular tone