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Drug Metab Dispos 30:446451 Muller PY, Dieterle F (2009) Tissue-specific, non-invasive toxicity biomarkers: translation from preclinical safety assessment to clinical safety monitoring

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However, the model adjusted for sex revealed a significant condition-by-sex interaction on Glx/tNAA change ( F 1,242 = 4.81, P = 0.029), with differences between placebo and naltrexone pretreatment conditions being more pronounced in males than in females (Fig

Across formulations, l-cystine and l-glutamate showed no significant differences in dose-normalized iAUC, C max , or T max , consistent with tight regulation of these circulating pools