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Approved in December 2025, it maintains the powerful GLP-1 mechanisms of its injectable counterpart without the need for injections

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Conventionally, lactate was perceived as a metabolic byproduct of glycolysis that accumulated under hypoxic conditions ( In 2019, lactate garnered public attention with a novel posture, following the discovery of a novel PTM of proteins by Professor Yingming Zhaos team, termed lactylation ( Recent research has unequivocally established the role of lactate in facilitating cancer progression ( 2 Lactate metabolism Lactate is conventionally understood as a metabolite generated through the glycolytic pathway under anaerobic conditions

This was considered a high-risk proposition because the GLP-1 receptor is a class B G protein-coupled receptor with a large extracellular domain that had been thought to require extensive peptide-receptor contacts for activation