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doi: 10.1126/science.abc8059 26 SchaumNLehallierBHahnOPlovicsRHosseinzadehSLeeSEet al

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Do not shake agitation can shear peptide bonds and denature the more delicate components

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Reconstituted peptide in aqueous solution is vulnerable to oxidation, hydrolysis at elevated temperatures, and microbial growth

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How BUD is determined: For 503A pharmacies, beyond-use dates are often based on published literature, USP 797 default dating rules, or general stability data for similar formulations

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