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203-207 A multicenter, randomized, controlled trial found acupuncture (18 sessions) was significantly more effective than standard pharmaceutical treatments (polyethylene glycol [PEG] given at 20 g/d for constipation-predominant IBS or pinaverium bromide given at 150 mg/d for IBS-D) for reducing IBS symptom severity scores on all domains after six weeks of treatment

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Reassuringly, non-clinical models, including a viral type 1 diabetes model, showed a minor impact of IL-21 blockade on the immune repertoire [55]

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The results were consistent, and the safety profile looked similar to other GLP-1 drugs

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