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Major adverse cardiovascular event (MACE) reduction in patients with type 2 diabetes with established cardiovascular disease has been firmly established in landmark cardiovascular outcomes trials such as LEADER (Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results), SUSTAIN-6 (Semaglutide in Subjects with Type 2 Diabetes), and REWIND (Researching Cardiovascular Events with a Weekly Incretin in Diabetes)

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This means that the drug helps increase insulin levels only when blood sugar is high, reducing the risk of hypoglycemia, a common issue with some diabetes treatments

Metabolic rate, starting weight, and existing dietary habits also shape first-month outcomes