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Description

Decreased expression of GPX4 leading to hemolytic anemia and increased splenic erythroid progenitor cells death was observed in mouse hematopoietic cells, and Altamura also noted that low expression of GPX4 corresponds to reticulocyte maturation problem ( The transient activation of cysteine aspartate specific protease-3 (Caspase-3) is necessary for erythroblasts maturation, and GATA-1 is also essential for the maturation of erythroblasts (Ribeil et al., 2007

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