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Even with close monitoring, the absence of clinical evidence supporting combination safety makes this approach high-risk and not recommended by major medical organizations

doi: 10.1089/ars.2009.2531 147 RitovVBMenshikovaEVAzumaKWoodRToledoFGSGoodpasterBHet al

They were able to do the synthesis by joining just two peptide fragments with an enzyme, omniligase-1, which catalyses amide bond formation, using fewer steps than most other methods

Although most incidents involved accidental dosing or therapeutic mistakes rather than intentional misuse, the sheer size of the increase surprised the research team