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Its entraining effects on circadian processes in brain cells, aligning neural activity and modulating synaptic transmission with the natural day-night cycle, could also potentially mitigate the development of AD
For the day 1 clinical measure scores (MADRS, QIDSSR, M3VAS, SHAPS, TEPS-A and TEPS-C), linear mixed-effects models were also used with condition (placebo and naltrexone), time (preinfusion and day 1 postinfusion), visit (visit 1 and visit 2) and the interaction between condition and time as fixed effects
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