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Conclusions/interpretation In people living with type 2 diabetes inadequately managed with GLP-1 RA therapy, with or without additional oral glucose-lowering medications, switching to once-weekly IcoSema in comparison with once-weekly semaglutide 1.0 mg demonstrated superiority in HbA 1c reduction, similar rates of clinically significant or severe hypoglycaemia, and similar frequency of gastrointestinal adverse events

Tan B, Pan X-H, Chew HSJ, Goh RSJ, Lin C, Anand VV, et al

Most patients experience the strongest nausea with their first injection and during dose increases, then adapt within 12 weeks at each dose level

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