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However, taking into account the potential undesirable effects of pharmacological interventions, there is a need to investigate them carefully and many different models may be used for that purpose

The foundation of success on GLP-1 medications is a combination of smart nutrition planning , consistent physical activity, adequate hydration, and proper medical monitoring

In the present study, it was observed that the liraglutide/GLP-1R axis acts in chondrocytes and macrophages to decrease inflammation and catabolism in vitro, which was confirmed by pain alleviation in vivo in mouse OA inflammatory pain model

For severely obese patients meeting criteria, bariatric surgery may be considered as it can produce significant improvement in liver fat, inflammation, and even fibrosis