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Methods: Thirty-six rats were allocated to six groups, one control group and five MTX groups, where induction of hepatotoxicity was achieved via injecting MTX (20 mg/kg)

AE: Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing original draft, Writing review & editing

This creates an unformulated aqueous solution with no permeation enhancers, no mucoadhesive polymers, no pH optimization for nasal mucosa (optimal range roughly pH 4.5 to 6.5), and no validated spray characteristics

The fat can also be used to correct other depressions or divots from previous surgery or injury