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mTORC1 is activated by glutamine (Gln), arginine (Arg), and Leucine (Leu), and activates protein synthesis by phosphorylation of eIF4E binding protein 1 (4E-BP1) and ribosomal protein S6 kinase 1 (S6K1)

The underlying mechanism involved thioredoxin 1-induced activation of mTORC1, which facilitated GPX4 synthesis and decreased ferroptosis

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Prevention of apoptosis-inducing factor translocation is a possible mechanism for protective effects of hepatocyte growth factor against neuronal cell death in the hippocampus after transient forebrain ischemia