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Contraindications Absolute contraindications I never compromise on: Current opioid medication use (LDN will block their effectiveness) Severe liver disease Pregnancy and breastfeeding (insufficient safety data) Relative contraindications requiring careful consideration: Organ transplant recipients taking immunosuppressive medications Active cancer treatment How I Monitor Success Success with Low Dose Naltrexone encompasses both measurable improvements and patient-reported changes: What I track: Reduced inflammatory markers (ESR, CRP), improved functional scores, decreased need for pain medications