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Metabolites are the ultimate products of metabolism and subsequently have the most direct bond to phenotype, providing readable information into the biochemical state of an organism and into perturbations in response to pathological conditions [21]

Hydrogels containing oxygen-releasing microspheres can promote re-epithelialization of diabetic wounds through continuous oxygen delivery to the wound site ( 4 Functional drug-loaded hydrogel bio-dressings promote drug release in response to stimulation The wound healing process involves a variety of cells and growth factors, and conventional dressings cannot regulate the release of active pharmaceutical ingredients in response to the healing process

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It is also possible that the relatively short duration and dosage used in this study were not sufficient to produce detectable changes in systemic Mg and Cu levels