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The p53 protein, a key human tumor suppressor, regulates the expression of oncogenes and downstream signaling pathways, contributing to biological effects (7275): Beyond its role in cancer, p53 is highly expressed in the brain, where it influences dendritic growth, oxidative stress response, apoptosis and autophagy, making p53 dysfunction and associated pathways noteworthy in the pathogenesis of AD (7678)

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Muscle loss concerns: Research shows that roughly one-quarter to one-third of weight lost on GLP-1 agonists comes from lean body mass rather than fat

To help the drugmaker recoup its costs (and encourage future pharmaceutical research), patents provide a period of market exclusivity