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S.RaivichG.GebhardtC.Da CostaC.NaumannH.VreugdenhilM.et al (2007)

Saxenda (Liraglutide) The Pioneer Saxenda was the first daily GLP-1 receptor agonist approved by the FDA for chronic weight management (2014)

They also reduce hepatic glucose output by decreasing hepatic FFA uptake and the expression of key gluconeogenesis enzymes such as PEPCK and G6Pase, while promoting hepatic sensitivity to insulin, transforming the liver from an "energy output organ" to an "energy storage organ"