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Definitely is shutting down that inflammatory response that's driving autoimmunity

We established an inducible Ire1-null mouse line by crossing the conditional Ern1 f/f mouse strain 28 ( Ern1 is the gene symbol for Ire1 in mice) with the Rosa26-CreERT2 strain 29 to generate the Ern1 f/f ;Rosa26-CreERT2 + mice

10.1111/j.1365-2990.2010.01135.x 141 GabrielliM.BonazziP.ScarpelliniE.BendiaE.LauritanoE

However, current therapeutic options have several limitations, including increasing drug tolerance, notable off-target effects, and severe adverse reactions