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doi: 10.1016/j.ab.2004.03.068

2023;6(2):e2254313

doi: 10.4103/2045-9912.385939

Past drugs had both modest efficacy (e.g., only 5% body weight loss) and/or serious side effects (e.g., fen-phen was used widely for weight loss in the 90s, but after the discovery that one of the components caused heart valve problems, it was recalled from the market2)