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frondosa with an average molecular weight of 66.1 kDa significantly upregulate glucose transporter 4 to improve glucose uptake in insulin resistant HepG2 cell induced by dexamethasone through activating insulin receptor substrate 1 (IRS-1)PI3Kc-JNK signaling pathway ( Amillariella mellea , Gomphidius rutilus , and Agrocybe cylindracea , respectively, showed better promotion of glucose uptake than those from Hypsizygus marmoreus , Pleurotus eryngii , and P

This cautious approach can be attributed to the historical context of Rimonabant, a previously promising anti-obesity agent withdrawn from the market in 2008 due to severe psychiatric side effects 26

Tirzepatide, on the other hand, takes a double-receptor approach, and it seems to provide more noticeable results