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10.1146/annurev-genom-083117-021320 Annu

Major guidelines, including the American Diabetes Association and obesity medicine societies, acknowledge that: Continuing treatment maintains benefits Stopping leads to regain for many people Decisions should be individualised and shared Some people will choose long-term treatment

Rodent studies using mitochondrial-targeted peptides exhibited lower reactive oxygen species and enhanced antioxidant enzyme activity, such as increased superoxide dismutase and glutathione peroxidase in ovarian and testicular tissue