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203 While structural details of the apo form are missing for this groups of Cu I sensors, ion mobility mass spectrometry studies on this protein suggest that metal binding subtly alters the shape of the tetramer to a more hydrodynamically compact structure 375 which may lead to changes in the surface electrostatic potential distribution similar to that observed for Sl CsoR

Most cell models rely on high concentrations of inducers (e.g., 10-50 M Erastin) to trigger acute ferroptosis within 624 hours, which cannot simulate the long-term metabolic disorders and heterogeneous pathological features of human DR or AMD (161)

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PC7, Proprotein Convertase 7