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doi: 10.1523/jneurosci.3203-08.2008 59 GuanJ

employed in osteoarthritis and cartilage regeneration research Pigs Used for pharmacokinetic profiling and oral bioavailability studies Cynomolgus monkeys 9-month chronic toxicology studies via oral gavage Human subjects Approximately 900 participants across six clinical trials examining safety and efficacy Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 25 years of research and extensive clinical testing, AOD-9604 faces substantial evidence gaps that have prevented therapeutic development

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For instance, in rodent models of colitis, administration of BPC-157 has been linked to a significant reduction in inflammatory markers and macroscopic signs of damage