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Interestingly, GSSG can also be reduced by NADPH

Loss of NRF2 function exacerbates the pathophysiology of sickle cell disease in a transgenic mouse model

Similarly, a recent phase 2 trial of Lixisenatide in early PD showed a stable motor score over 12 months ( 0.04 points), contrasting with a decline in the placebo group (+ 3.04 points), resulting in an adjusted mean difference of 3.08 points ( p = 0.007)