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The ultra-long half-life raises a potential concern: if adverse effects occur, they may take longer to resolve after discontinuation compared to shorter-acting agents

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However, it is unlikely that osmotic lysis has any significant role in normal red cell destruction because there is no site within the vascular compartment where the plasma is sufficiently hypotonic to bring lysis about

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The third possible cause is acquired histamine problems, which arise, for example, as part of a vegan diet

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doi:10.53738/REVMED.2017.13.547.0215

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