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Aging Cell 19 , e13133 (2020)

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Induction of programmed cell death DAMPs are involved in apoptosis, pyroptosis, and necrosis of cardiomyocytes, which not only leads directly to cardiomyocyte loss, but also further amplifies the inflammatory response and exacerbates myocardial injury and cardiac dysfunction through the release of pro-inflammatory factors and recruitment of immune cells