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The cause of the disease is not clear, but genetic factors related to the polymorphism of the HLA-Cw6 gene are most often indicated

In 119 G6PD-deficient (hemizygous or homozygous) children with malaria who received 7.5 mg/kg of dapsone over 3 days, the drop in hemoglobin averaged about 2 g/dL, with a nadir on day 7

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Conversely, nicotine may exert paradoxical inhibitory effects by activating immune pathways and inducing apoptosis, such as through stimulation of immature dendritic cells via PI3K/Akt signaling and modulation of caspase-3 and Cyclin B1 expression through 7-nAChR signaling [36]