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Senolytic elimination of senescent macrophages restores muscle stem cell function in severely dystrophic muscle

Dysfunction of the carnitine transporter OCTN2 is the cause of Primary Carnitine Deficiency (PCD), which is characterized by systemic loss of carnitine with severe clinical manifestations, including fertility issues in both males and females

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Deficiency may cause fatigue, neurological symptoms, and cognitive changes, with treatment often improving symptoms when deficiency is present