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Peer review Peer review information Nature Metabolism thanks Florian Greten, Luisa Iommarini and the other, anonymous, reviewer(s) for their contribution to the peer review of this work

However, recent successes with weight-lowering incretin-based medicines have raised expectations for pharmaceutical pipelines to transform the management of type 2 diabetes

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1 Table 1 Extraglycemic effects of glucagon-like peptide-1 receptor agonists (From Mudaliar S, Henry RR